南瓜子的研究进展

(350007):,,,,LDL,,,,,,,,,:;;;:R28217:A:100623765(2003)0220011203ABriefReviewontheStudyofPumpkinSeedsWUGuo2xin,LIYong2xing,CHENMi2yu,HONGYan2fei(TheBioengineeringCollege,FujianNormalUniversi2ty,Fuzhou350007)ABSTRACT:Inthispaper,astudyprogresswasreviewedbrieflyonchemicalcomposition,pharmacoligicaleffects,clini2calapplicationsofPumpkinseeds(SemenMoschatae).Pumpkinseedscontainseveralmajorgroupsofconstituents:fattyacids,phytosterins,aminoacids,vitaminsandmineralsubstances.Theyhavesuchfunctionsasdrivingoutparasites,loweringcholesterol,preventingoxidation,resistinginflammation,reducinghypertension,decreasingpressureontheblad2derandurethral,withverylowtoxicity.Theyhavetheirclinicalapplicationsinteniasis,chistosomiasis,prostatitis,be2nignprostatichyperplasia,bladderstimulussymptomsandurolithiasis.KEYWORDS:Pumpkinseeds(SemenMoschatae);chemicalcompositions;pharmcoligicaleffects;Clinicalapplications(SemenMoschatae),,(CucurbitamoschataDuch),,,,,,,,,1LDL,,,,,,,,,,,,,,,1,1.21.8cm,0.71cm,,,,,,,,,,122.1:,,,,,,,,,11,14-,9,11-,,,,,252.2,,,,,,572.3,,,,,,,,,,,,,,89,2.4B1,B2,C,E,PP,9112.59102.612,,,,,33.1,13,,14,153.2,(40mg.Kg-1)Felodipine(0.45mg.Kg-1)11StraitPharmaceuticalJournalVol15No.22003Captoril(9mg.Kg-1),,FelodipineCaptoril,163.3,,,173.4Freunds,,-,,183.550%,E,2,()193.6,Simvatatin3,,,LDL-,HDL-SimvatatinSimvatatin,,Simvatatin,203.7SD7d4mg.kg-1,5mg.kg-110d20d30d,,PCNAbcl22:PCNAbcl22213.8SuphakarnVS2027:();5mg.kg-1.d-1;60mg.kg-1.d-1;24h,PH:,,,223.9Hageman(HFf,2a)HagemanHFfa234,,121355.1100150g,90150g,,30min200500ml,0.52h2530g90%100%24265.2,:27%,8%,6%,4%,41%15%,,275.3,2245BPH(BPH),12,12(I-PSS),(LQ-In2dex),41.6%,46%46%,28,-Curbicin,53,,,,,295.4,(250g),3,714d..(DISA2100DroSystem)(V)(MFR)(AFR)(T),,(RVR=T/MFK).:,,,,305.52331,2.260mg,212003152,,6,,,LDL,,,,,,,,,1..:,2002,13211323.2,,,.GC-MS.,2002,23(3):115116.3Dutta,sahas,Palp.CA,1986,105:149708f4EmakovAI,ArtyuginaZD.CA,1982,97:123957C5TsuyakiH.CA,1989,110:133909q6TsuyakiH,etal.CA,1986,102:183973m7MatusZ,MolnarP,SzaboLG.Maincarotenoidsinpressedseeds(Cucur2bitaesemen)ofoilpumpkin(Cucurbitapepoconvar.pepovar.styriaca).ActaPharmHung1993Sep;63(5):24756.8.(),,,1991,73.9SchenkelE,etalCA,1993,118:55556w10.(),,,1991,27.11MurkovicM,HillebrandA,WinklerJ,PfannhauserW.(1996)Vari2abilityofvitaminEcontentinpumpkinseeds(CucurbitapepoL.).ZLebensmUntersForsch;202(4):2758.12El-AdawyTA,TahaKM.Characteristicsandcompositionofwatermel2on,pumpkin,andpaprikaseedoilsandflours.JAgricFoodChem;2001,49(3):12539.13,,,.,,1980,1(2):124.14,,,.,,1962,9(6):327.15,,,2002,15:(6).16ZuhairHA,AbdEl-FattahAA,El-SayedMI.Pumpkin-seedoilmodulatestheeffectoffelodipineandcaptoprilinspontaneouslyhyperten2siverats.PharmacolRes.2000,May;41(5):55563.17,,.,,1989,182.18FahimATAbdelFattahAAAghaAMGadMZEffectofpumpkin-seedoilontheleveloffreeradicalscavengersinducedduringadjuvant-arthri2tisinrats.PharmacolRes(1995Jan)31(1):739119KroyerG,HartmannT&WashttlJ,Proceedingsofthe8thWorldCongressofFoodScienceandTechnology,Toronto,199120alZuhairH,AbdelFattahAA,AbdelLatifHA.Efficacyofsimvastatinandpumpkinseedoilinthemanagementofdietary-inducedhypercholes2terolemia.PharmacolRes.1997May;35(5):4038.21.,,1999,8;5(4):25826.22SuphakarnVS,YarnnonC,NgunboonsriP.Theeffectofpumpkinseedsonoxalcrystalluriaandurinarycompositionsofchildreninhyperendemicarea.AmJClinNutr1987;45:11521.23HojimaYPierceJVPisanoJJPumpkinseedinhibitorofhumanfactorXI2Ia(activatedHagemanfactor)andbovinetrypsin.Biochemistry(1982Aug3)21(16):3741624,,.11,,1996,16(4):5825,.50,,1996,5(1):19126.56;();1996,8(2):50127.45.,2001,19(8):2627128FriederichM,TheurerC,Schiebel-SchlosserG.ProstaFinkFortecap2sulesinthetreatmentofbenignprostatichyperplasia.Multicentricsurveillancestudyin2245patients.ForschKomplementarmedKlassNaturheilkd2000Aug;7(4):2004.29CarbinBE,EliassonR.TreatmentbyCurbicininbenignprostatichyper2plasia(BPH).SwedJBiolMed1989;2:79130,..,1990,5(2):9193.31SuphiphatV,MorjaroenN,PukboonmeI,etal.TheeffectofpumpkinseedssnackoninhibitorsandpromotersofurolithiasisinThaiadolescents.JMedAssocThai1993;76:48793.200319:2000715,,,:,,,,;,,,,,:,;200341,(23)31StraitPharmaceuticalJournalVol15No.22003