生命质量在风湿病临床中的应用

,(19891991),15%,218%,,,7575%,10%(1990):2116%,416%;16441215%,654312%[1],(rheumatoidarthritis,RA)(systemiclupuserythematosus,SLE)(ankylosingspondylitis,AS)(dermatomyositis,DM),,Fries5D,(death),(disability),(discomfort),(dollarcosts),(drugtoxicity)[2](19901994),,DALYs()11361454,DALYs5139%,105945RA,RADALYs9618%9914%[3],,,,,,203040,(qual2ityoflife,QOL),70,,1,1978WHO:200032,();(),,,,1993,WHO,,[4],,,,()(),(),;,,,,,,,(health2relatedqualityoflife),,,2211:scale,,,,,30,,,9812001653ChinJRheumatol,June2001,Vol5,No.3©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,??,?,??,212:20,,(genericQOLinstrument),,,,,(specificQOLinstrument),,(arthritis2specificQOLinstrument)AIMS(arthritisim2pactmeasurementscales),,,,Whalley,,,,,,;,,,,,[5]213:SF236(MOS362ItemShort2FormHealthSurvey)(Nottinghamhealthprofile)(qualityofwellbeing,QWB)LeeHAQMHAQ(healthassessmentquestionnaire)AIMSMHIQ(Mc2Masterhealthindexquestionnaire)PET(problemelicitationtechnique,MACTAR)[527]3,4Lee(1993),HAQMHAQ,8,,;AIMS,9,69MHIQ:24;25;25;PET,,,,,,,29,,[8]214:,,A85,B92,B,BA,,,,,Saaty,3:,,,,,,:,,,,,,,,,0912001653ChinJRheumatol,June2001,Vol5,No.3©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,,,1JorgeMT,JeanYR,MarcCH.Rheumaticandmusculoskeletaldis2easesandimpairedqualityoflife:achallengeforrheumatologists.JRheumatol,1996,23:12312JamesFF.Quality2of2lifeconsiderationswithrespecttoarthritisandnonsteroidalanti2inflammatorydrugs.AmJMed,1998,104:14s220s13,HendersonG,HigginbothamN,1:()1:,199711222414RubenBA.Assessmentofqualityoflifeinchildrenwithrheumaticdisease.JRheumatol,1999,26:14322143515OrtizZ,SheaB,DieguezMG,etal.Theresponsivenessofgenericqualityoflifeinstrumentsinrheumaticdiseases:asystematicreviewofrandomizedcontrolledtrials.JRheumatol,1999,26:210222116FriesJF,SpitsP,HolmanHR.Measurementofpatientsoutcomeinarthritis.ArthritisRheum,1980,23:137214517FriesJF,SpitsP,KrainesRG,etal.Measurementofpatientoutcomeinarthritis.ArthritisRheum,1980,23:146215218,,,11,1999,8:92121(:2000208207)(:),,,,:,315,,220005275,,,,()2,,,,,,HLA2B27(-),(ESR)29mm/1h,(RF)(-),,,,,20kg:37,12/min,92/min,100/60mmHg,,,,,,,,4(+),34,,,:2588g/L,(116316)109/L,(2441)109/L,RFANAENA:100730();();():,=12121,37%,,,,Auers,,,,:M2:5,2,,1,,,,ANLLM2()[1],,,210[2,3]5,,,1SternsRS,VakevaLH.NonctaneousmalignanttumorsinthePUVAfollow2upstudy:197521976.JInvestDermatol,1997,108:897290012,,,1:331,1999,31:8328513,,111,1994,7:3901(:2000207203)(:)1912001653ChinJRheumatol,June2001,Vol5,No.3©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.